Blakely Lab

The Blakely Lab

Randy Blakely, Ph.D.

Randy Headshot

Allan D. Bass Professor of Pharmacology and Psychiatry

Director, Silvio O. Conte Center for Neuroscience Research

Director, Vanderbilt Postdoctoral Training Program in Neurogenomics


at Florida Atlantic University

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Randy D. Blakely, Ph. D.
Executive Director, FAU Brain Institute
Director, Silvio O. Conte Center for Neuroscience Research

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My laboratory explores mechanisms of synaptic regulation, focusing on how clearance of neurotransmitters by presynaptic and glial transporters regulates neurotransmitter signaling capacity. We use molecular biology, transcriptomic and proteomic methods, model system genetics (C. elegans, recombinant inbred mice), molecular and cellular imaging approaches, electrophysiological paradigms, and transgenic mouse approaches to identify mechanisms by which neurotransmitter transporters insure normal synaptic function and how disease risk is impacted by transporter dysfunction. We also seek to understand how drugs, including antidepressants (e.g. SSRIs) and psychostimulants (e.g. cocaine, ADHD medications) carry out their actions. Finally, we seek to understand the web of molecular interactions that act in concert with, or regulate neurotransmitter transporters to insure proper synaptic signaling and plasticity.

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Congratulations to Daniel Bermingham, who successfully defended his PhD thesis, The Conserved MAP Kinase SWIP-13/ERK8 Regulates Dopamine Signaling Through Control of the Presynaptic Dopamine Transporter, on April 26, 2016.

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Congratulations to Alex Nackenoff on successfully defending his PhD thesis, Determination of Requisite SERT Antagonism for the Acute and Chronic Behavioral and Biochemical Antidepressant Effects of SSRIs, as Revealed Utilizing the SERT Met 172 Mouse Model, on March 14th, 2016.

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Congratulations to Elizabeth Ennis on successfully defending her PhD thesis, Identification and Characterization of Novel Inhibitors of the Presynaptic, Hemicholinium-3-Sensitive Choline Transporter on February 12, 2016.

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Congratulations to Meagan Quinlan for receipt of a travel award to present her work at the 2016 Meeting of the International Society for Serotonin Research.

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Established in 2007, the Next Generation award recognizes Society for Neuroscience's chapter members who have made outstanding contributions to public communication, outreach and education about neuroscience. Congratulations to Nicole Baganz for winning this year's award for her efforts with the local chapter of NAMI, outreach efforts with yoga, neuroscience and Eastern medicine, and organizing Vanderbilt's Music and Mind Exposition.

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Congrats to Neuroscience Ph.D. Student Gwynne Davis for awarding of a Fellowship from the National Institute of Mental Health to pursue “In Vivo Modeling of Heritable Dopamine Transporter Dysfunction Associated with Neuropsychiatric Disorders”

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Congratulations to Dr. Matthew Robson for receiving a two-year NARSAD Young Investigator Award from the Brain and Behavioral Research Foundation.

Silvio O. Conte FAU Brain Institute